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Using two separate drugs to lose weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people who go through it you ought to err along the side of caution and allow FDA do its job and demand some study be done so your public knows the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies are in business to generate money and that they would say almost anything to keep people on their medications. Researchers found that participants taking this drug for a year, dropped excess weight within 4 weeks and have kept the body weight off through the 56 weeks in the study. Contrave is really a combination from the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which are made up of multiple active ingredient, that might make them more efficient and safer. Combo-pilling could be the newest fad or even better the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular is the fact that since right now there are no long term prescription weightloss pills that have been approved by the FDA besides orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug may also raise blood pressure and heartbeat, and mustn't be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure level and heart rate and must stop used in patients with uncontrolled high blood pressure, in addition to by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients for the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation. "There were no signs and symptoms of depression or suicidal thoughts in trial participants," said Fujioka.