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The Promises Treatment Centers, estimates that between five and 10 % of the patients at his doctors are treated with naltrexone. Those more than likely to receive it are people with a history of early relapse—whoever has been treated before and have not had time to maintain sobriety for a lot more than thirty days. Using two separate drugs to lose weight naturally can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight reduction and the people that go through it one should err assisting caution and allow FDA do its job and demand some study be done so the public knows the side effects and hazards of the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say anything to keep people on their own medications. Researchers found out that participants investing in this drug for any year, lost weight within one month and have kept the weight off during the entire 56 weeks of the study. Contrave is a combination of the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which might be made up of many active ingredient, which may make them more effective and safer. Combo-pilling is the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that since right now there aren't long term prescription slimming capsules that have been licensed by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be licensed by the FDA. Seizures really are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug can also raise blood pressure levels and heartbeat, and shouldn't be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must 't be used in patients with uncontrolled high blood pressure levels, and also by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients which has a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation. "There were no signs and symptoms of depression or suicidal thoughts in trial participants," said Fujioka.